Spirocyclic cyclohexane compounds

US7960404B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Stefan Schunk · Aachen, DE
• Derek Saunders · Aachen, DE
• Stephanie Harlfinger · Basel, CH
• Sonja Steufmehl · Linnich, DE

Key dates

• Filing date: Aug 21, 2009
• Grant date: Jun 14, 2011
• Expiry date: Aug 21, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Spirocyclic cyclohexane compounds corresponding to formula Iin which R1 and R2 form a pyrrolidine ring or an azetidine ring and which exhibit increased metabolic stability, a process for producing such spirocyclic cyclohexane compounds, pharmaceutical compositions containing such spirocyclic cyclohexane compounds, and the use of such spirocyclic cyclohexane compounds to treat or inhibit pain and/or other disorders.