Patent · US Active

Polynucleotides encoding anticoagulant antibodies

US7960532B2 · kind B2 · utility

0Cited by
19References
5Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 16, 2009
Grant dateJun 14, 2011
Priority date—
Expiry dateJul 16, 2029

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N2800/224
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

This invention relates to novel antibodies that bind with greater affinity to the factor VIIa/tissue factor (FVIIa/TF) complex than to tissue factor (TF) alone, do not compete for binding to TF with FVII and FX, an inhibit FX activation. The antibodies bind at the site of injury and prevent the initiation of thrombosis. The antibodies can be used to treat a variety of thrombotic conditions including but not limited to deep vein thrombosis, disseminated intravascular coagulation, and acute coronary syndrome.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.