Patent · US Active

Solid forms of a chemokine receptor antagonist and methods of use thereof

US7960549B2 · kind B2 · utility

0Cited by

9References

16Claims

0Family size

Inventors

Carole Neves · Paris, FR
Aurelia Chevalier · Dreux, FR
Pascal Billot · Paris, FR

Key dates

Filing date	Dec 19, 2005
Grant date	Jun 14, 2011
Priority date	—
Expiry date	Mar 12, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D491/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The citrate salt of (S)-4-(4-Chloro-phenyl)-1-{3-[7-(1-hydroxy-1-methyl-ethyl)-11H-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-ylidene]-propyl}-3,3-dimethyl-piperidin-4-ol, which may be used in pharmaceutical applications, is disclosed. The crystalline Citrate Salt, including particular single crystal forms and combinations of the single crystalline forms, are also discussed. Mixtures for forming the crystalline salts are discussed. As well, methods of producing the Citrate Salt, and crystalline forms thereof, and using such Citrate Salt, and crystalline forms thereof, in treating diseases associated with aberrant leukocyte recruitment, activation, or recruitment and activation are also discussed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.