Polypeptide complex that regulates cell cycle and anergy
US7964369B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 9, 2004 |
| Grant date | Jun 21, 2011 |
| Priority date | — |
| Expiry date | Dec 21, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/886
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An active ubiquitin E3 ligase, GRAIL, is crucial in the induction of anergy in cells of the immune system, and in the regulation of cellular proliferation. GRAIL is shown to associate with, and be regulated by Otubain isoforms, including OTUBAIN-1 (DOG, the Destabilizer of GRAIL) and an alternative reading frame splice variant of OTUBAIN-1 (SOG, the Stabilizer of GRAIL). These proteins play opposing roles in the regulation of GRAIL auto-ubiquitination and consequently on its ability to induce anergy and regulate cellular proliferation. DOG serves as an adaptor protein, recruiting the DUB USP8. One major substrate for USP8 is the Ras exchange factor Ras-GRF1, and this protein can be found in a complex with USP8 and GRAIL, which complex is ubiquitinated by GRAIL.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.