Conjugates and compositions for cellular delivery

US7964578B2 · kind B2 · utility

Assignee

• Sirna Therapeutics, Inc. · US

Inventors

• Chandra Vargeese · Schwenksville, US
• Peter Haeberli · Berthoud, US
• Weimin Wang · Hangzhou City, CN
• Tongqian Chen · Longmont, US

Key dates

• Filing date: Oct 16, 2008
• Grant date: Jun 21, 2011
• Expiry date: Feb 3, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including cholesterol, folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HSA) derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.