Synthesis and use of novel inhibitors and inactivators of protein arginine deiminases

US7964636B2 · kind B2 · utility

Assignee

• UNIVERSITY OF SOUTH CAROLINA · US

Inventors

• Paul R. Thompson · Columbia, US
• Yuan Luo · Tangxia, CN

Key dates

• Filing date: Nov 7, 2006
• Grant date: Jun 21, 2011
• Expiry date: Mar 16, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/4192
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one embodiment of the present disclosure, an inactivator of protein arginine deiminase 4 is disclosed. The inactivator includes: (I) and x includes F; Cl, and H, y includes OH and NH2, R includes H, an alkyl group, an alkenyl group, an alknyl group, and n is greater than 0.