Inhibitors of Taspase1 protease activity
US7964700B2 · kind B2 · utility
1Cited by
1References
24Claims
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Key dates
| Filing date | Sep 6, 2007 |
| Grant date | Jun 21, 2011 |
| Priority date | — |
| Expiry date | Mar 6, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/6478
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.