Method for reconstructing the distribution of fluorophores in a non-homogeneous medium by optical tomography in continuous mode

US7965389B2 · kind B2 · utility

Assignee

• COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · FR

Inventors

• Anabela Da Silva · Marseilles, FR
• Anne Koenig · Meylan, FR
• Lionel Herve · Meylan, FR

Key dates

• Filing date: Apr 24, 2007
• Grant date: Jun 21, 2011
• Expiry date: Feb 21, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2211/424
• WIPO field: Computer technology
• WIPO sector: Electrical engineering

Abstract

The method enables a non-homogeneous diffusing object to be examined by illuminating the object with a continuous light by means of a light source. It previously comprises reconstruction of the three-dimensional spatial mapping of an attenuation variable representative of the diffusion and absorption non-homogeneities of the object, by resolving a diffusion equation∇2F({right arrow over (r)}S, {right arrow over (r)})−k′2({right arrow over (r)})F({right arrow over (r)}S, {right arrow over (r)})=ASδ({right arrow over (r)}−{right arrow over (r)}S).In the diffusion equation, AS is a constant, {right arrow over (r)} the spatial coordinate of any point of the mesh of a volume at least partially containing the object, and {right arrow over (r)}S the spatial coordinate of the light source. The transfer functions of an equation used for reconstructing the distribution of fluorophores integrate the attenuation variable reconstituted in this way.