Nucleic acids and corresponding proteins entitled 191P4D12(b) useful in treatment and detection of cancer

US7968090B2 · kind B2 · utility

Assignee

• Latency, LLC · US

Inventors

• Arthur B. Raitano · Los Angeles, US
• Pia M. Challita-Eid · Calabasas, US
• Aya Jakobovits · Beverly Hills, US
• Mary Faris · Los Angeles, US
• Wangmao Ge · Tampa, US

Key dates

• Filing date: Jun 22, 2010
• Grant date: Jun 28, 2011
• Expiry date: Jun 22, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 191P4D12(b) gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P4D12(b) can be used in active or passive immunization.