Biochips including ion transport detecting structures and methods of use

US7968305B2 · kind B2 · utility

Assignee

• AVIVA BIOSCIENCES CORPORATION · US

Inventors

• Xiaobo Wang · San Diego, US
• Lei Wu · San Diego, US
• Jun Xu · Gaithersburg, US
• Ming Huang · San Diego, US
• Weiping Yang · San Diego, US
• Jing Cheng · Beijing, CN
• Jia Xu · San Diego, US

Key dates

• Filing date: Mar 22, 2002
• Grant date: Jun 28, 2011
• Expiry date: Jun 21, 2026

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/049
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention recognizes that the determination of ion transport function or property using direct detection methods, such as patch-clamps, whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and methods of use that allow for the direct analysis of ion transport function or property using microfabricated structures that can allow for automated detection of ion transport function or property. These biochips and methods of use thereof are particularly appropriate for automating the detection of ion transport function or property, particularly for screening purposes.