Melanocortin receptor-specific piperazine compounds with diamine groups

US7968548B2 · kind B2 · utility

Assignee

• Palatin Technologies, Inc. · US

Inventors

• Shubh D. Sharma · Cranbury, US
• Yi-Qun Shi · East Brunswick Township, US
• Kevin D. Burris · Washington Crossing, US
• Zhijun Wu · Plainsboro, US
• Papireddy Purma · Plainsboro, US
• Yadi Reddy Bonuga · Plainsboro, US

Key dates

• Filing date: Aug 11, 2006
• Grant date: Jun 28, 2011
• Expiry date: Apr 14, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Melanocortin receptor-specific compounds with diamine groups of the general formulaand pharmaceutically acceptable salts thereof, where W is a diamine heteroatom unit with at least one cationic center, hydrogen bond donor or hydrogen bond acceptor, J, Q, L1, L2, L3, R1a, R1b, R2a, R2b and X are as defined in the specification, and the carbon atom marked with an asterisk can have any stereochemical configuration. Compounds disclosed herein bind to one or more melanocortin receptors and may be an agonist, a partial agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist as to one or more melanocortin receptors, and may be employed for treatment of one or more melanocortin receptor-associated conditions or disorders, including specifically treatment of obesity and related conditions.