Chromenoneindoles

US7968551B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Kai Schiemann · Darmstadt, DE
• Henning Bottcher · Darmstadt, DE
• Timo Heinrich · Groß-Umstadt, DE
• Gunter Holzemann · Seeheim-Jugenheim, DE
• Christoph van Amsterdam · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Joachim Leibrock · Gauting, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE

Key dates

• Filing date: Mar 8, 2004
• Grant date: Jun 28, 2011
• Expiry date: Aug 11, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Chromenoneindole derivatives of the formula (I), in which R1, R2, R3, R, A and B are as defined in Claim 1, and pharmaceutically usable prodrugs, derivatives, solvates, stereoisomers and salts thereof, exhibit particular actions on the central nervous system, in particular 5-HT reuptake-inhibiting and 5-HTx-agonistic and/or -antagonistic actions. They are distinguished by particularly high bioavailability and particularly high inhibition of 5-HT reuptake.