1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments

US7968591B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Stefan Oberboersch · Aachen, DE
• Bernd Sundermann · Aachen, DE
• Corinna Sundermann · Aachen, DE
• Edward Bijsterveld · Nijmegen, NL
• Hagen-Heinrich Hennies · Simmerath, DE

Key dates

• Filing date: Dec 9, 2008
• Grant date: Jun 28, 2011
• Expiry date: Dec 9, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides corresponding to formula Imethods for their production, pharmaceutical compositions containing them, and the use thereof for noradrenalin receptor regulation, particularly for inhibiting noradrenalin reuptake, and/or for 5-HT receptor regulation, particularly for inhibiting 5-hydroxy tryptophan reuptake, and/or for opioid receptor regulation and/or for batrachotoxin (BTX) receptor regulation and/or for treating or inhibiting pain and other conditions.