Process for the purification of Ropinirole hydrochloride

US7968731B2 · kind B2 · utility

Assignee

• Alembic Ltd. · IN

Inventors

• Pandurang Balwant Deshpande · Vadodara, IN
• Ashok Prataprai Shanishchara · Vadodara, IN
• Trushar Rajanikant Shah · Vadodara, IN
• Hitarth Harshendu Acharya · Vadodara, IN
• Parven Kumar Luthra · Vadodara, IN

Key dates

• Filing date: Mar 21, 2007
• Grant date: Jun 28, 2011
• Expiry date: Jan 24, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.