Method of promoting delivery of an antioxidant agent to a cell expression neuroligin

US7972601B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Palmer Taylor · Village of La Jolla, US
• Davide Comoletti · San Diego, US
• Lori Jennings · San Diego, US
• Robyn Flynn · Calgary, CA

Key dates

• Filing date: May 10, 2005
• Grant date: Jul 5, 2011
• Expiry date: May 4, 2026

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are methods and compositions for treating autism spectrum disorders by administering an antioxidant or agent that stabilize or enhance expression of altered neuroligins. An aspect of the disclosure includes site-specific delivery of the antioxidant to the endoplasmic reticulum (ER) to reverse incorrect disulfide binding of the protein neuroligin. Also disclosed is a method of targeting the antioxidant to neuroligin by using the calcium binding or other recognition site of neuroligin to bind the antioxidant. The antioxidant can be cysteamine linked to a molecule which binds to a binding site.