Angiopoietin-like 2 as a biomarker of vascular endothelial cell abnormal function and senescence
US7972795B2 · kind B2 · utility
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Key dates
| Filing date | Jun 20, 2007 |
| Grant date | Jul 5, 2011 |
| Priority date | — |
| Expiry date | Apr 14, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/515
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for assessing a physiological state of a mammal. The method includes: obtaining from the mammal a biological sample; measuring the expression of angiopoietin-like 2 in the biological sample; and assessing the physiological state of the mammal by comparing the measured expression of the angiopoietin-like 2 to a predetermined normal expression level in normal subjects, wherein an increase in angiopoietin-like 2 level over the predetermined normal expression level indicates an abnormal physiological state.
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