Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US7977049B2 · kind B2 · utility
29Cited by
60References
71Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 8, 2005 |
| Grant date | Jul 12, 2011 |
| Priority date | — |
| Expiry date | Nov 5, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.