Production of functional antibodies in filamentous fungi
US7977067B2 · kind B2 · utility
13Cited by
21References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 9, 2004 |
| Grant date | Jul 12, 2011 |
| Priority date | — |
| Expiry date | Aug 1, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described herein are methods for the production of monoclonal antibodies in filamentous fungi host cells. The monoclonal antibodies are expressed as full-length fusion proteins that retain functional antigen binding and antibody-dependent cellular cytotoxicity capabilities. Improvements in the cleavage of the glucoamylase-light chain fusion protein to yield a mature antibody are also provided. The antibodies produced in filamentous fungi show equivalent pharmacokinetic disposition to antibodies produced in mammalian cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.