Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
US7977078B2 · kind B2 · utility
33Cited by
31References
39Claims
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Key dates
| Filing date | Aug 24, 2008 |
| Grant date | Jul 12, 2011 |
| Priority date | — |
| Expiry date | Aug 24, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.