Combinations of antibodies selective for DR5 and other therapeutic agents
US7981421B2 · kind B2 · utility
11Cited by
13References
58Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 13, 2010 |
| Grant date | Jul 19, 2011 |
| Priority date | — |
| Expiry date | Jan 13, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.