Patent · US Active

Cleavage of precursors of insulins by a variant of trypsin

US7981635B2 · kind B2 · utility

2Cited by

25References

11Claims

0Family size

Assignees

Sanofi-Aventis Deutschland GMBH · DE
Roche Diagnostics Operations, Inc. · US

Inventors

Frank Zocher · Frankfurt am Main, DE
Christoph Hoh · Frankfurt am Main, DE
Rainer Mueller · Penzberg, DE
Erhard Kopetzki · Penzberg, DE
Frank Geipel · Penzberg, DE
Stephan Glaser · Seeshaupt, DE

Key dates

Filing date	Aug 26, 2006
Grant date	Jul 19, 2011
Priority date	—
Expiry date	Dec 31, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N9/6427
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to the production of a variant of recombinant trypsin with increased substrate specificity for arginine versus lysine in non-animal host organisms. Moreover, the present invention relates to a variant of recombinant trypsin and their production. Also provided are use of recombinant porcine pancreatic trypsin variants for cleavage of precursors of insulins, and kits containing the variant of trypsin.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.