L-lysine-producing corynebacteria and process for the preparation of L-lysine

US7981640B2 · kind B2 · utility

Assignee

• EVONIK DEGUSSA GMBH · DE

Inventors

• Caroline Kruetzer · Melle, DE
• Stephan Hans · Osnabrück, DE
• Mechthild Rieping · Bielefeld, DE
• Bettina Mockel · Bielefeld, DE
• Walter Pfefferle · Bodenwerder, DE
• Lothar Eggeling · Jülich, DE
• Sahm Hermann · Jülich, DE
• Miroslav Patek · Praha, CZ

Key dates

• Filing date: Oct 10, 2008
• Grant date: Jul 19, 2011
• Expiry date: Sep 12, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P13/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially the dapA gene and the lysC gene (aspartate kinase gene), are enhanced and, in particular, over-expressed, and a process for the preparation of L-lysine.