Methods and compositions for targeting proteins across the blood brain barrier
US7981864B2 · kind B2 · utility
21Cited by
50References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 19, 2008 |
| Grant date | Jul 19, 2011 |
| Priority date | — |
| Expiry date | May 19, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods and compositions for targeting therapeutic proteins to the brain. Methods and compositions of the invention involve associating an IGF moiety with a therapeutic protein in order to target the therapeutic protein to the brain. Soluble fusion proteins that include an IGF targeting moiety are transported to neural tissue in the brain from blood. Methods and compositions of the invention include therapeutic applications for treating lysosomal storage diseases. The invention also provides nucleic acids and cells for expressing IGF fusion proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.