Patent · US Active

Process for the preparation of olanzapine

US7981884B2 · kind B2 · utility

0Cited by

1References

17Claims

0Family size

Assignee

EGIS GYOCYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG · HU

Inventors

Gyorgyi Kovanyine Lax · Budapest, HU
Gábor Németh · Budapest, HU
György Krasznay · Budapest, HU
Norbert Mesterházy · Szombathely, HU
Kalman Nagy · Budapest, HU
Gyorgyi Vereczkeyne Donath · Budapest, HU
Zsuzsanna Szent-Kirallyi · Budapest, HU

Key dates

Filing date	Nov 10, 2006
Grant date	Jul 19, 2011
Priority date	—
Expiry date	Sep 16, 2027

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P25/18
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to a process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine (olanzapine) of the formula (I) by reacting 4-amino-2-methyl-10H-thieno[2,3-b][1/5]benzodiazepine hydrochloride of the formula (II) with N-methylpiperazine in an organic solvent, which comprises carrying out the reaction in the mixture of toluene and 1,3-dimethyl-2-imidazolidinone. The invention also encompasses new 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b] [1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB), the preparation thereof and pharmaceutical compositions comprising said new compound.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.