Application of 2-bromide-isovanillin for the manufacture of a medicament for anti-cancer or/and radiation/chemotherapy sensitization

US7981939B2 · kind B2 · utility

Assignee

• Institute of radiation medicine, academy of military medical sciences, PLA. · CN

Inventors

• Pingkun Zhou · Beijing, CN
• Yuqian Yan · Beijing, CN
• Lin Wang · Qingdao, CN
• Jianli Sui · Beijing, CN

Key dates

• Filing date: Feb 25, 2008
• Grant date: Jul 19, 2011
• Expiry date: Dec 18, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Use of 2-bromo-isovanillin in the preparation of an anticancer medicament and/or radio- and chemotherapy sensitizing medicament is disclosed. The medicament for the treatment of cancers and/or for radio- and chemotherapy sensitization comprising 2-bromo-isovanillin as active ingredient provided herein has the following features: (1) low toxicity, without evident adverse effects; (2) significant therapeutic effect, with remarkable proliferation inhibiting and pro-apoptotic effects in tumor cells; (3) a broad-spectrum anticancer activity; (4) suitable to be used in combination with antimetabolites, to enhance the effects and meanwhile lower the toxicity, and also to reduce multi-drug resistance; (5) convenient and safe administration, the main route being oral.