Patent · US Active

System for monitoring the location of transgenes

US7982022B2 · kind B2 · utility

11Cited by

20References

6Claims

0Family size

Assignee

Mayo Foundation for Medical Education and Research · US

Inventors

Stephen James Russell · Rochester, US
John Morris · Los Alamos, US

Key dates

Filing date	Dec 15, 2009
Grant date	Jul 19, 2011
Priority date	—
Expiry date	Dec 15, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/705
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A novel strategy for monitoring the location of a transgene in a mammal is disclosed. A sodium iodide symporter is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of the transgene confers the activity of the sodium iodide symporter (NIS) to a host cell which expresses the transgene. Subsequent administration of labeled iodine results in transport of the labeled iodine into the cell bearing the NIS, which can then be localized and measured using standard imaging techniques. The system is particularly useful for monitoring the location of therapeutic transgenes and tissue-specific distribution of the therapeutic gene product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.