Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions

US7985747B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Stephan Georg Mueller · Warthausen, DE
• Klaus Rudolf · Warthausen, DE
• Philipp Lustenberger · Warthausen, DE
• Dirk Stenkamp · Biberach, DE
• Alexander Dreyer · Ochsenhausen, DE
• Kirsten Arndt · Biberach, DE
• Gerhard Schaenzle · Biberach, DE
• Henri Doods · Warthausen, DE
• Marco Santagostino · Magenta, IT
• Fabio Paleari · Monza, IT

Key dates

• Filing date: Feb 17, 2010
• Grant date: Jul 26, 2011
• Expiry date: Feb 17, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the CGRP antagonists of general formulawherein A, X, D, E, G, M, Q and R1 to R3 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.