Patent · US Active

Compositions and methods for increasing bone mineralization

US7985834B2 · kind B2 · utility

2Cited by

43References

5Claims

0Family size

Assignee

Celltech R&D Limited · GB

Inventors

David G. Winkler · Arlington, US
John Latham · Seattle, US
Jiye Shi · Slough, GB

Key dates

Filing date	Jul 16, 2009
Grant date	Jul 26, 2011
Priority date	—
Expiry date	Jul 16, 2029

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/108
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A novel class or family of TGF-β binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.