Piperidinyl derivatives as modulators of chemokine receptor activity

US7985861B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Percy H. Carter · Princeton, US
• Cullen L. Cavallaro · Lawrence, US
• John V. Duncia · Newtown, US
• Daniel S. Gardner · Furlong, US
• John Hynes · Washington Crossing, US
• Rui-Qin Liu · Montgomery, US
• Joseph B. Santella · Springfield, US
• Dharmpal S. Dodd · Princeton, US

Key dates

• Filing date: Jul 20, 2009
• Grant date: Jul 26, 2011
• Expiry date: Jul 20, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/107
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using said modulators are disclosed.