Use of allogeneic cell lines to load antigen presenting cells to elicit or eliminate immune responses
US7988963B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 16, 2000 |
| Grant date | Aug 2, 2011 |
| Priority date | — |
| Expiry date | Dec 22, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2239/58
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel antigen-presenting cells, including but not limited to dendritic cells, that are loaded with antigens from dead or dying cells including allogenic cell lines, and the methods for making such antigen-presenting cells are described. These loaded antigen-presenting cells induce therapeutic immune responses in humans. Such loaded antigen-presenting cells are useful in the management of cancer. Antigen-loaded dendritic cells prepared as described here can prime naïve T cells to differentiate into effector cells able to recognize multiple and/or shared tumor antigens that are expressed either on the tumor cells that are used to load the dendritic cells and/or on other tumor cells. The cytotoxic T cells generated by exposure to antigen-loaded dendritic cells prepared as described here can be used in adoptive therapy. This induction of responses against multiple antigens shared between different cells, for instance tumor cells, as described here is important as it leads to broad immune responses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.