Antitubercular extracts of Salicornia brachiata

US7989004B2 · kind B2 · utility

Assignee

• COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH · IN

Inventors

• Meena Rajnikant Rathod · Sayla, IN
• Bhupendra Shethia · Sayla, IN
• Jayant Pandya · Sayla, IN
• Pushpito Kumar Ghosh · Bhavnagar, IN
• Prakash Dodia · Sayla, IN
• Brahm Srivastava · Sidhauli, IN
• Ranjana Srivastava · Lucknow, IN
• Anil Srivastava · Lucknow, IN
• Vinita Chaturvedi · Darsi, IN
• Mariappanadar Vairamani · Darsi, IN

Key dates

• Filing date: Jan 23, 2006
• Grant date: Aug 2, 2011
• Expiry date: Jan 23, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to enhancement of anti-tubercular activity of active fraction isolated from Salicornia brachiata. The invention also discloses the non-toxic nature of the fraction and positively identifies Sucrose as its main constituent. Pure Sucrose is shown to have no anti-tubercular activity indicating thereby that activity of the fraction resides in one or more of the minor constituents. The minor constituents are shown to be relatively low molecular weight entities and a chromatographic technique is disclosed for separating them from the bulk sucrose to probe their activities and structures in detail, as also the possibility of their synthesis if the leads thrown up are novel.