Method of identifying a compound capable of modulating the Th2 polarization of CD4+ lymphocytes
US7989172B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Sep 16, 2005 |
| Grant date | Aug 2, 2011 |
| Priority date | — |
| Expiry date | May 2, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods utilizing novel target genes related to immune-mediated diseases, such as asthma, allergy and autoimmune diseases. The invention is based on a molecular level description of the polarization of CD4+ precursor cells (Thp) from which T helper cells are known to originate. Particularly, the present invention provides a method of identifying a compound capable of modulating the polarization of CD4+ lymphocytes. The invention is also related to a method for assessing the presence of, or disposition to, an immune-related disorder in a subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.