Method of classifying human subjects having adolescent idiopathic scoliosis
US7989175B2 · kind B2 · utility
3Cited by
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9Claims
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Key dates
| Filing date | Sep 11, 2008 |
| Grant date | Aug 2, 2011 |
| Priority date | — |
| Expiry date | Jun 26, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for classifying human subjects having adolescent idiopathic scoliosis (AIS) into AIS subgroups, comprising detecting an impairment in the melatonin-signaling pathway in a cell sample from the subject, wherein the impairment is detected by an accumulation of cyclic adenosine 5′-monophosphate (cAMP) in the cell sample as compared to a control sample in the presence of a known melatonin-signaling pathway agonist, wherein the results of the detection step enable the classification of the subject having AIS into an AIS subgroup.
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