Compositions and methods for producing gamma-carboxylated proteins
US7989193B2 · kind B2 · utility
3Cited by
17References
49Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Apr 10, 2006 |
| Grant date | Aug 2, 2011 |
| Priority date | — |
| Expiry date | Sep 27, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/64
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a γ-glutamyl carboxylase and associated control sequences. The invention further relates to a method of producing a protein requiring gamma-carboxylation in high yields.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.