Therapeutic compounds

US7989438B2 · kind B2 · utility

Assignee

• Istituto di Recerche di Biologia Molecolare P. Angeletti S.R.L. · IT

Inventors

• Immacolata Conte · Roma, IT
• Joerg Habermann · Roma, IT
• Angela Mackay · Basel, CH
• Frank Narjes · Ariccia, IT
• Maria del Rosario Rico Ferreira · Roma, IT
• Ian Stansfield · Roma, IT

Key dates

• Filing date: Jul 15, 2008
• Grant date: Aug 2, 2011
• Expiry date: Jun 25, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D515/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A class of macrocyclic compounds of formula (I), wherein R7, A, Ar, B, D, F, M, Q1, Q2, W, X, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.