Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments
US7989451B2 · kind B2 · utility
2Cited by
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30Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 31, 2006 |
| Grant date | Aug 2, 2011 |
| Priority date | — |
| Expiry date | Dec 21, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/056
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula Iand to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.