4-arylamin-or-4-heteroarylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof

US7989462B2 · kind B2 · utility

Assignee

• Myrexis, Inc. · US

Inventors

• Sui Xiong Cai · San Diego, US
• Mark B. Anderson · Salt Lake City, US
• Adam Willardsen · Sandy, US
• Nilantha Sirisoma · San Diego, US
• Hong Zhang · Shenyang, CN
• Kazuyuki Suzuki · Murray, US

Key dates

• Filing date: Jul 3, 2007
• Grant date: Aug 2, 2011
• Expiry date: Oct 22, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.