Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process
US7989467B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 6, 2004 |
| Grant date | Aug 2, 2011 |
| Priority date | — |
| Expiry date | Oct 18, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases related to the process of splicing pre-messenger RNAs in the cell, such as Frasier syndrome, frontotemporal dementia linked to chromosome 17 (a form of Parkinson's disease), Leigh syndrome (a type of encephalopathy), atypical cystic fibrosis, certain neuropathologies including Alzheimer's disease linked to a mutation in the Tau protein, muscle atorphy which affects the SMN (Survival of Motor Neuron) gene, depression linked to a serotonin splicing impairment, and certain cancers in which the global splicing process is affected (e.g. breast cancer, colon cancer and certain lymphomas), as well as viral diseases such as AIDS.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.