Modulators of cellular adhesion

US7989626B2 · kind B2 · utility

Assignee

• SAR code Corporation · US

Inventors

• Wang Shen · San Mateo, US
• Kenneth J. Barr · San Francisco, US
• Johan D. Oslob · Sunnyvale, US
• Min Zhong · Palo Alto, US

Key dates

• Filing date: Feb 4, 2011
• Grant date: Aug 2, 2011
• Expiry date: Feb 4, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds having formula (I):and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).