Methods for determining whether a compound alters the amount of at least one αβ (X-41) peptide and the amount of either total αβ or at least one αβ (X-40) peptide produced by a non-human mammal

US7993627B2 · kind B2 · utility

Assignees

• Elan Pharmaceuticals, Inc. · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Martin Citron · Thousand Oaks, US
• Dennis J. Selkoe · Brookline, US
• Peter A. Seubert · South San Francisco, US
• Dale B. Schenk · Burlingame, US

Key dates

• Filing date: Dec 30, 2002
• Grant date: Aug 9, 2011
• Expiry date: Mar 6, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2821
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides methods of screening compounds for their ability to alter the production of Aβ(x≧41) alone or in combination with Aβ(x≦40). The methods involve administering compounds to cells, specifically measuring the amounts of Aβ(x≦40) and Aβ(x≧41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.