Polypeptides having binding affinity for HER2

US7993650B2 · kind B2 · utility

Assignee

• AFFIBODY AB · SE

Inventors

• Jörgen Carlsson · Uppsala, SE
• Stefan Ståhl · Stockholm, SE
• Tove Eriksson · Nacka, SE
• Elin Gunneriusson · Hallsberg, SE
• Fredrik Nilsson · Stockholm, SE

Key dates

• Filing date: Jun 30, 2004
• Grant date: Aug 9, 2011
• Expiry date: Jun 8, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.