Patent · US Active

Nanoparticles comprising a nanoparticle template and a polymer shell having an amide side chain, and method of making thereof

US7993749B2 · kind B2 · utility

7Cited by
7References
22Claims
0Family size

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Key dates

Filing dateAug 17, 2007
Grant dateAug 9, 2011
Priority date—
Expiry dateJun 20, 2029

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10T428/2998
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Acid-labile poly(N-vinyl formamide) (“PNVF”) nanocapsules were synthesized by free radical polymerization of N-vinyl formamide with optional active ingredients on the surface of silica nanoparticles. Polymerization in the presence of a novel cross-linker that contains an acid-labile ketal facilitated stable etching of silica nanoparticle templates using sodium hydroxide and recovery of PNVF nanocapsules. The formamido side group of PNVF was then hydrolyzed by extended exposure to sodium hydroxide to produce polyvinylamine (“PVAm”) nanocapsules. PNVF and PVAm nanoparticles are also synthesized that form nanogels with optional active ingredients.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.