Method and probes for the detection of a tumor-specific fusion protein
US7993850B2 · kind B2 · utility
0Cited by
9References
16Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 6, 2009 |
| Grant date | Aug 9, 2011 |
| Priority date | — |
| Expiry date | Aug 6, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/108331
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to the detection of fusion proteins. Described are a set of at least a first and a second molecular probe, each probe provided with a dye wherein the dyes together allow energy transfer, at least one probe provided with a reactive group allowing juxtaposing at least the first and second probes wherein the reactive group allows modulation of juxtaposing the probes such that there is an increased likelihood of energy transfer between the dyes. A method is provided which permits detecting the presence of a fusion protein in a cell at the single cell level.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.