Device containing cytophilic islands that adhere cells separated by cytophobic regions

US7993905B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• Massachusetts Institute of Technology · US
• Children's Medical Center Corporation · US

Inventors

• Rahul Singhvi · Cambridge, US
• Amit Kumar · San Ramon, US
• George M. Whitesides · Newton, US
• Donald E. Ingber · Boston, US
• Gabriel P. Lopez · Albuquerque, US
• Daniel I. C. Wang · Duxbury, US
• Gregory Stephanopoulos · Pasadena, US

Key dates

• Filing date: Jul 1, 2008
• Grant date: Aug 9, 2011
• Expiry date: May 2, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B60/14
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).