Oxygen-18 labeled organic acids and use in diagnosing metabolic disorders
US7993931B1 · kind B1 · utility
5Cited by
1References
43Claims
0Family size
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Inventor
Key dates
| Filing date | Oct 28, 2003 |
| Grant date | Aug 9, 2011 |
| Priority date | — |
| Expiry date | Jan 19, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are methods and compositions for quantitatively measuring the amount of an unlabeled organic acid in a sample. Oxygen-18 labeled organic acids are used as internal standards to adjust for the loss of a structurally similar or identical unlabeled organic acid through processing required for its detection, such as by mass spectrometry. The methods of the invention are useful for diagnosing inborn errors of metabolism in an individual by quantitating signature organic acids in body fluids such as urine or plasma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.