Micro-RNAs that modulate smooth muscle proliferation and differentiation and uses thereof
US7994150B2 · kind B2 · utility
1Cited by
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37Claims
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Key dates
| Filing date | Feb 23, 2009 |
| Grant date | Aug 9, 2011 |
| Priority date | — |
| Expiry date | May 1, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the identification of microRNAs that regulate smooth muscle cell proliferation and differentiation, including the miR-143/miR-145 cluster. Methods of treating restenosis and neointima formation by increasing expression of miR-143 and/or miR-145 are disclosed. The present invention also relates to the identification of two microRNAs, miR-486 and miR-422a, that regulate cell survival in the heart. Methods of treating or preventing cardiac hypertrophy, heart failure, or myocardial infarction by increasing expression of miR-486 and/or miR-422a in heart tissue are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.