6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists

US7994163B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• John Gordon Allen · Newbury Park, US
• Karin Briner · Indianapolis, US
• Christopher Stanley Galka · Carmel, US
• Richard C. Hoying · Indianapolis, US
• Maria Angeles Martinez-Grau · Madrid, ES
• Julie M. Miyashiro · Skokie, US
• Natalia Pokrovskaia · New Westminster, CA
• Matthew Robert Reinhard · Indianapolis, US

Key dates

• Filing date: Sep 1, 2006
• Grant date: Aug 9, 2011
• Expiry date: Jul 6, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: R6 D R?N—R″R* where R6 is —(CrC3)alkyl-S—(C0-C3)alkyl-R10, —(C1-C3)alkyl-NR11R12, —(CrC3)alkyl-O—R13. and other substituents are as defined in the specification.