Hexahydro-pyrazino[1,2-A]pyrimidine-4,7-dione derivatives substituted with amino acids

US7994168B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Petra Lennig · Mainz, DE
• Siegfried Stengelin · Frankfurt am Main, DE
• Thomas Klabunde · Frankfurt, DE
• Matthias Gossel · Frankfurt am Main, DE
• Pavel Safar · Tucson, US
• James Spoonamore · Tucson, US
• Gregory H. Merriman · Somerville, US
• Joseph T. Klein · Bound Brook, US
• Brian K. Whiteley · Lebanon, US
• Carolina Lanter · Audubon, US
• Kenneth J. Bordeau · Myerstown, US
• Zhaoxia Yang · Belmont, US
• Martin Smrcina · Tucson, US

Key dates

• Filing date: Feb 21, 2007
• Grant date: Aug 9, 2011
• Expiry date: Nov 27, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives substituted with amino acids, and to the physiologically tolerated salts thereof, processes for their preparation and their use as medicaments.