Process for preparing fluoromethyl-substituted heterocyclic compounds

US7994207B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Thomas Zierke · Böhl-Iggelheim, DE
• Michael Rack · Eppelheim, DE

Key dates

• Filing date: Dec 20, 2007
• Grant date: Aug 9, 2011
• Expiry date: Dec 20, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing fluoromethyl-substituted heterocyclic compounds of the general formula (I)in which R1 is H or F; R2 is an -[A-O]m—R3 group in which A is C2-C4-alkanediyl, R3 is C1-C4-alkyl and m is 1 or 2;by converting the corresponding chloromethyl-substituted compounds (II) in the presence of fluorinating agents,to processes for preparing the chloromethyl-substituted compounds (II),to processes for preparing amides of the general formula (IV)and to compounds of the general formulae (I) and (II).