Methods and compositions for sequencing a nucleic acid

US7994304B2 · kind B2 · utility

Assignee

• Helicos Biosciences Corporation · US

Inventors

• Suhaib Siddiqi · Raleigh, US
• Hernan Orgueira · Cambridge, US
• Edyta Olejnik · Brookline, US
• Subramanian Marappan · Acton, US
• Philip Buzby · Brockton, US
• Atanu Roy · Stoneham, US

Key dates

• Filing date: Oct 30, 2007
• Grant date: Aug 9, 2011
• Expiry date: Dec 28, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs.